Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Cocoa
Cocoa is a city in Brevard County, Florida. The population was 17,140 at the 2010 United States Census.[1] It is part of thePalm Bay–Melbourne–Titusville Metropolitan Statistical Area.
Several stories circulate among Cocoa old timers as to how the town got its name. One story says that the mail used to come by river boat and was placed in an empty tin box labeled Baker’s Cocoa. The box was nailed to a piling in the river next to downtown. Additionally, an early hotel in the area, located on the Indian River lagoon, was named Cocoa House.[4]
In 1885, the S. F. Travis Hardware store opened. It is still in business in 2014.[5]
Cocoa’s business district was destroyed by fire in 1890, but soon, significant development began to occur with the extension of the Jacksonville, St. Augustine, and Indian River Railway to Cocoa.[citation needed]
The city was chartered in 1895.[6] In the winter of 1894-1895, Cocoa experienced a second economic setback when the “Great Freeze” destroyed the citrus crop and forced many citrus workers to seek new occupations. According to one source, by 1903, the population of Cocoa had dropped to 382.
During the second decade of the 20th century, population growth and economic development in Cocoa accelerated. The state business directory of 1911-1912 set the population at 550. By 1925, the population was estimated at 1,800. During the Great Depression, the local economy declined and the two local banks failed. Still, by 1930, the population had risen to 2,200.[citation needed]